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. 2022 Oct 19;2022:3067526. doi: 10.1155/2022/3067526

Figure 5.

Figure 5

Effects of 5-Loxin on the serum levels of inflammatory markers (5-LOX, FLAP, COX-2, LTB4, and PGE2). The values represent the mean ± SD (n = 8). Normal: normal rats; Control: MIA-induced osteoarthritis rats; INDO: MIA-induced osteoarthritis rats administered indomethacin (2 mg/kg body weight); 5-Loxin® 100: MIA-induced osteoarthritis rats administered 5-Loxin® (100 mg/kg body weight); 5-Loxin® 200: MIA-induced osteoarthritis rats administered 5-Loxin® (200 mg/kg body weight). Significance: ###p < 0.001vs. normal rat values and ∗p < 0.05, ∗∗p < 0.01, ∗∗∗p < 0.001vs. MIA control rat values.