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. 2022 Sep 7;610(7933):752–760. doi: 10.1038/s41586-022-05309-5

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Extended Data Fig. 6 — a, tdTomato labeling in cDC and TC from mLN of DC fate-mapping RORγt and Aire double reporter (Clec9a^Cre/+R26^lsl-tdTomatoRorc^{Venus-creERT2}Aire^GFP) mice at P18. b, Flow cytometry analysis of TCRβ⁺, MHCII⁺ ILC3, and CXCR6^–MHCII⁺ cells encompassing TCs and DCs, from mLN of RAG1 fate-mapped (Rag1^creERT2R26^lsl-YFP) mice (n = 3) at P15 following 4-OHT treatment on P3, 5 and 7. c, Schematic of DC and TC ontogeny demonstrating distinct and overlapping transcriptional regulators and cell surface markers. d, Flow cytometry analysis of indicated immune cell subsets from mLN of RORα fate-mapped Rorc^Venus mice and summary bar graph for tdTomato labeling. e, UMAP of RORγt⁺MHCII⁺ cells (Fig. 2b) with scVelo-projected velocities, shown as streamlines. f, IL7R (CD127) expression (representative of n = 4 mice) on ILC3s and TCs. g, Expression of IL7R by DC subsets. Each dot represents an individual mouse, (n = 4). Data in a,b,d,f,g are representative of 2-3 independent experiments.

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