Extended Data Fig. 1. Analysis of pTreg cell generation in mice harboring MHC class II-deficient RORγt⁺ APCs.

a, Quantification of total pTreg (RORγt⁺Foxp3⁺) and CD4⁺ T_eff (Foxp3^–CD44^hi) cells in the mesenteric lymph nodes (mLN) and large intestine lamina propria (LI) of 3-week-old MHCII^ΔRORγt and control (H2-Ab1^fl/fl) mice (n = 7 or 8 mice per group). b, pTreg (RORγt⁺Foxp3⁺) and T_H17 (Foxp3^–CD44^hiRORγt⁺) cells in mLN and LI of 8-week-old MHCII^ΔRORγt (n = 4) and control (n = 3) mice. Data in a pooled from two independent experiments. Data in b representative of three independent experiments. Error bars: means ± s.e.m. Statistics were calculated by unpaired two-sided t-test; *P < 0.05; ***P < 0.01, ****P < 0.0001.

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