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. 2022 Oct 12;610(7933):796–803. doi: 10.1038/s41586-022-05314-8

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — a, Schematic representation of protein constructs that co-purified with TMC-1. EF1–EF3, EF-hand domains; TM, transmembrane domain. b, Local resolution map of the native TMC-1 complex after 3D reconstruction. c, Overall architecture of the native TMC-1 complex, viewed parallel to the membrane. TMC-1 (dark blue and light blue), CALM-1 (orange and yellow) and TMIE (red and pink) are shown in a cartoon diagram. Lipid-like molecules, N-glycans and putative ions are coloured black, green, and dark red, respectively. d, Cytosolic view of the reconstructed map fit to the model. Subunit densities are coloured as in c and the detergent micelle is shown in grey. e, A top-down extracellular view of the TMC-1 complex shows the domain-swapped dimeric interface. α-helices are represented as cylinders.