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. 2022 Oct 12;610(7933):796–803. doi: 10.1038/s41586-022-05314-8

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — a, The location of the pore (gold mesh) is shown in the context of the TMC-1 complex. Putative calcium ions are shown as red spheres. b, An expanded view of the ion permeation pathway, highlighting pore-lining residues, shown as sticks, and putative ions (red). c, van der Waals radius of the pore plotted against the distance along the pore axis, calculated by MOLE 2.0. d, The electrostatic potential of pore-lining residues is depicted in different colours: grey, nonpolar; yellow, polar; red, acidic; and blue, basic. Acidic and basic residues are labelled. e, Multiple sequence alignment of selected residues from TMC-1 putative pore-forming helices.