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. 2022 Oct 12;610(7933):704–712. doi: 10.1038/s41586-022-05275-y

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Extended Data Fig. 6 — Stratified SNP-based heritability ( $h_{SNP}^{2}$ ) estimates were obtained from a partition of the genome into two sets of 1000 Genomes imputed SNPs with a minor allele frequency (MAF) >1%: (1) SNPs within +/− 35 kb of GWS (GWS loci) vs. all other SNPs. Analyses were performed in samples of five different ancestry groups: European (EUR; UK Biobank only), African (AFR), East Asian (EAS) and South Asian (SAS) as described in the legend of Fig. 3. Estimates from stratified analyses were compared with SNP-based heritability estimates obtained from analysing HM3 SNPs only (dotted horizontal violet bar).

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