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. 2022 Oct 26;12:17956. doi: 10.1038/s41598-022-22806-9

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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IL-10 effect on GABA current amplitude in oocytes injected with human α1β2γ2 cDNA. The bar-graph represents the mean and ± s.e.m. of the I_GABA amplitudes evoked from oocytes intranuclearly injected with α1β2γ2 cDNAs before (black) and after (red) the incubation with IL-10 (200 ng/mL, 3 h; n = 8; p > 0.05 by paired t-test).The I_GABA amplitudes recorded after the IL-10 incubation were normalized to the response obtained before exposure to IL-10 for each cell (range of current amplitudes: from 247.5 to 1119.0 nA), then averaged and expressed as a percent variation. Traces depict representative currents measured after 4 s application of GABA (white bar, 50 μM) in oocytes injected with α1β2γ2 cDNAs before (black trace) and after (red trace) IL-10 incubation (for 3 h). Grey bar on the right trace represents the block by 100 μM bicuculline (representative of 4 experiments).