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. 2022 Oct 26;12:17956. doi: 10.1038/s41598-022-22806-9

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Time-course effect of IL-10 on GABA current amplitude in oocytes microinjected with GG tissue. GABA alone was applied at 250 μM at the beginning of each experiment (time zero) and at various time points after treatment with 100 ng/ml IL-10. Data (mean ± s.e.m.; n = 6–12 oocytes/time point; patients #8–12 in Table 1) represent the percentage increase of the peak amplitude induced by IL-10. Data were normalized to the mean current amplitude recorded at time zero (23.7 ± 8.6 nA, n = 12). Inset: Traces depict representative GABA currents at the indicated times. * = p < 0.05 by Wilcoxon signed rank test; ** = p < 0.01 by paired t-test.