Table 1.
Clinical cases used for electrophysiology and immunohistochemistry.
| Pathology | Gender | Age (years) | Duration epilepsy | Seizure types | Brain area | Seizures/month | Mutation | ASMs |
|---|---|---|---|---|---|---|---|---|
| 1. TSC | m | 47y | 46y | FB/TC | T | > 50 | TSC2 | VPA, CBZ |
| 2. TSC | f | 17y | 17y | FS | F | > 50 | TSC2 | LEV, VPA, VGB, OXC |
| 3. TSC | f | 30y | 30y | FS | F | 10–20 | TSC2 | LMT, LEV |
| 4. TSC | m | 35y | 34y | FB/TC | F | > 50 | TSC2 | LEV, VGB, CLB |
| 5. TSC | m | 8y | 8y | FS/SE | T | 20–30 | TSC2 | VGB, LMT, CLB |
| 6. TSC | f | 9y | 9y | FS | F | > 50 | TSC2 | LMT, CBZ |
| 7. TSC | m | 2y | 2y | FS | F | > 50 | TSC2 | VGB, LEV |
| 8. GG* | m | 50y | 48y | FS | T | 20–30 | BRAF | LEV, CBZ |
| 9. GG* | m | 1y | 1 m | FS | T | > 50 | BRAF | LEV |
| 10. GG* | f | 23y | 1y | FS | T | > 50 | BRAF | LMT |
| 11. GG | m | 41y | 11y | FS | T | 30–40 | BRAF | LMT, TPM |
| 12. GG | m | 17y | 2y | FB/TC | F | 20–30 | BRAF | CBZ, CLB |
m Male, f Female, y Year, m Month, SE Status epilepticus, FS Focal seizures, FB/TC Focal bilateral/tonic clonic, F Frontal, T Temporal, CBZ Carbamazepine, CLB Clobazam, LEV Levetiracetam, LMT Lamotrigine, OXC oxcarbazepine, TPM Topiramate, VGB Vigabatrin, VPA Valproate. Tissues from all the patients have been used to perform electrophysiology experiments with IL-10 or IL-1β. *Patients marked with asterisks have also been used to test the IL-10 after the incubation with IL-1β.