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. 2022 Oct 26;12:17915. doi: 10.1038/s41598-022-21169-5

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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miR-25-5p negatively regulates signaling pathways in ROS response and apoptosis of the brain of septic rats. (A) Effects of AAV-miR-25-5p on miR-25-5p, TXNIP, catalase, and MnSOD mRNA fold changes (A), and TXINP, catalase, cleaved caspase-1, NLRP3, and MnSOD protein fold changes in the brain of septic rats (B). The relative expression levels of miRNA and mRNA were determined by qPCR and protein levels were determined by western blotting. The independent t-test was applied to the comparison between groups. Values are shown as the mean ± SD (A, and B). Con: negative control, LPS: lipopolysaccharide, AAV: adeno-associated virus. *P < 0.05. **P < 0.01. ***P < 0.001. ****P < 0.0001.