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. 2022 Oct 26;13:6345. doi: 10.1038/s41467-022-33946-x

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — a Significant KEGG pathways enriched by mRNAs in the miRNA-target regulatory network. Green dots: genes; red circles: enriched KEGG pathways with FDR < 0.05; barplot denotes the number of cancer types with altered miRNAs. Y-axis denotes |fold change|. b Significant KEGG pathways enriched by mRNAs in the TF-target regulatory network. Green points: genes; red circle: enriched KEGG pathways with FDR < 0.05; barplot denotes the number of cancer types with altered TFs. The y axis denotes |fold change|.