Table 1.
Demographic characteristics by AT stages
| All (n = 314) | A-T- (n = 202) | A + T- (n = 88) | A + T + (n = 24) | p | |
|---|---|---|---|---|---|
| Age, years | 61.1 (4.7) | 60.5 (4.3) | 61.7 (5.1) | 64.3 (4.7) | < 0.001 |
| Women, n (%) | 196 (62.4) | 130 (64.4) | 49 (55.7) | 17 (70.8) | 0.253 |
| APOE-ε4 carriers, n (%) | 170 (54.1) | 84 (41.6) | 72 (81.8) | 14 (58.3) | < 0.001 |
| Plasma GFAP*, pg/ml | 136 (55) | 121 (42) | 153 (66) | 201 (53) | < 0.001 |
| CSF GFAP§, pg/ml | 4303 (2197) | 3985 (2045) | 4178 (1740) | 7415 (2573) | < 0.001 |
| CL | 3.0 (17.0) | -4.6 (6.5) | 12.5 (17.3) | 31.9 (27.1) | < 0.001 |
| Time PET-LP, days | 107 (66) | 109 (63) | 101 (67) | 111 (88) | 0.571 |
| Time PET-MR, days | 145 (71) | 146 (66) | 140 (71) | 150 (98) | 0.767 |
Mean and SD are shown unless otherwise stated. AT groups were derived from previously published thresholds on CSF Aβ42/40 and p-tau [1].*Thirteen values missing. § Two values missing. Abbreviations: A-T-, Aβ-negative tau-negative; A + T-, Aβ-positive tau-negative; A + T + , Aβ-positive tau-positive; APOE, apolipoprotein-E; CL, Centiloids; CSF, cerebrospinal fluid; GFAP, glial fibrillary acidic protein; LP, lumbar puncture; SD, standard deviation