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. 2022 Jul 5;49(13):4616–4641. doi: 10.1007/s00259-022-05870-1

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© The Author(s) 2022

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — Pre-targeting system for imaging of ECM remodeling. Protective antigen binds to the cell membrane in the presence of MMP-2, -9, and/or -14 allowing to form a pore in the membrane. Hereafter, an indium-111 labeled LF.^E687A is administered which selectively binds to the cleaved protective antigen, and enters the cells via the created pore. The figure is based on Xavier et al. [84]