Table 2.

Effects of the intervention on the mean cortical thickness of the global or lobar areas

	Baseline, mm			Changes (from baselines to study end), mm			p-value*
Cortical areas	FMI (n = 20)	HMI (n = 19)	Control (n = 16)	FMI (n = 20)	HMI (n = 19)	Control (n = 16)	FMI vs. Control	HMI vs. Control	FMI vs.HMI
Global mean	3.095 (0.090)	3.108 (0.080)	3.126 (0.110)	0.033 (0.070)	−0.004 (0.050)	−0.003 (0.040)	0.013	0.732	0.050
AD signature region	3.529 (0.253)	3.529 (0.246)	3.578 (0.272)	0.031 (0.140)	−0.001 (0.101)	−0.000 (0.117)	0.054	0.726	0.192
8 ROI using lobe atlas*
Parietal	2.885 (0.117)	2.93 (0.104)	2.949 (0.119)	0.026 (0.077)	−0.001 (0.065)	0.002 (0.047)	0.0723	0.4548	0.158
Occipital	2.951 (0.151)	2.925 (0.142)	2.921 (0.157)	0.009 (0.124)	−0.044 (0.081)	−0.04 (0.063)	0.0418	0.4548	0.120
Frontal	3.095 (0.093)	3.106 (0.108)	3.129 (0.108)	0.039 (0.063)	0.004 (0.042)	0.006 (0.028)	0.0095	0.4548	0.048
Isthmus	3.325 (0.19)	3.315 (0.117)	3.358 (0.207)	0.026 (0.107)	0.001 (0.069)	−0.006 (0.083)	0.0583	0.4548	0.199
Parahippocampal	3.32 (0.134)	3.339 (0.078)	3.402 (0.126)	0.035 (0.088)	0.01 (0.043)	0.007 (0.06)	0.0723	0.4548	0.161
Cingulate	3.115 (0.139)	3.098 (0.084)	3.144 (0.133)	0.043 (0.073)	0.011 (0.04)	0.008 (0.039)	0.0085	0.4548	0.048
Temporal	3.354 (0.097)	3.369 (0.094)	3.391 (0.121)	0.039 (0.101)	−0.006 (0.055)	−0.006 (0.048)	0.0145	0.4548	0.081
Insula	3.635 (0.108)	3.638 (0.139)	3.682 (0.174)	0.048 (0.047)	−0.004 (0.048)	−0.0 (0.052)	0.0085	0.4548	0.002

Data are presented as the mean (standard deviation)

AD Alzheimer’s disease, FMI facility-based multidomain intervention, HMI home-based multidomain intervention

^*Analysis with a false discovery rate threshold of p < 0.05 to control for multiple comparisons