Table 2.

Morphometric analysis of spines. Spine morphological analysis in control and after ACR16 (70 nM) and PRE-084 treatments evaluating relative amount (percentage (%), mean ± SEM) of stubby spines (no clear neck) thin and mushroom spines (both presenting a neck). An analysis by Student’s t-test was used here for data analysis. Significant statistical differences are as follows: (a) stubby spines, ACR16 compared to control: ***(p < 0.001), PRE-084 compared to control: ***(p < 0.001), PRE-084 compared to ACR16: ***(p < 0.001), (b) mushroom spines, ACR16 compared to control: ***(p < 0.001), PRE-084 compared to control: ***(p < 0.001), PRE-084 compared to ACR16: ***(p < 0.001). No significant differences were observed for thin spines

	Spine classes
	Stubby (mean ± SEM)	Thin (mean ± SEM)	Mushroom (mean ± SEM)
Control	17.01 ± 0.33	15.45 ± 0.52	67.56 ± 0.55
ACR16 (70 nM)	23.59 ± 0.57	17.49 ± 0.94	58.91 ± 1.06
PRE-084 (50 nM)	39.70 ± 0.89	17.72 ± 1.29	42.60 ± 1.17