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. 2022 Oct 13;12:953932. doi: 10.3389/fonc.2022.953932

Table 3.

Clinicopathological features of cutaneous CVC, GCA, and PEH.

Clinicopathological features VC, N = 21, n (%) GCA, N = 21, n (%) PEH, N = 21, n (%) Value of p
Exudation and crusting 21/21 (100) 10/21 (48) 14/21 (67) p < 0.01
 Induration 21/21 (100) 3/21 (14) 16/21 (76) p < 0.01
 Irregular borders  21/21 (100) 7/21 (33) 17/21 (81) p < 0.01
 Warty surface 19/21 (90) 21/21 (100) 5/21 (24) p < 0.01
Growth pattern p < 0.01
 Endophytic 0/21 (0) 0/21 (0) 18/21 (86)
 Exophytic 0/21 (0) 21/21 (100) 0/21 (0)
 Exo-endophytic 21/21 (100) 0/21 (0) 3/21 (14)
Koilocytotic cells 0/21 (0) 19/21 (90) 1/21 (5) p < 0.01
The depth of acanthosis p < 0.01
 Papillary dermis 0/21 (0) 19/21 (90) 18/21 (86)
 Reticular dermis 21/21 (100) 2/21 (10) 3/21 (14)
Morphologic features of acanthosis p < 0.01
 Blunt with pushing margins 18/21 (86) 1/21 (5) 2/21 (10)
 Papillomatous 0/21 (0) 17/21 (81) 1/21 (5)
 Irregular 3/21 (14) 3/21 (14) 18/21 (86)
Severe keratinization 21/21 (100) 2/21 (10) 3/21 (14) p < 0.01
Degree of dermal inflammation p < 0.01
 Mild 0/21 (0) 11/21 (52) 3/21 (14)
 Moderate 5/21 (24) 7/21 (33) 11/21 (52)
 Severe 16/21 (76) 3/21 (14) 7/21 (33)
Basal cell mild atypia 10/21 (48) 2/21 (10) 9/21 (43) p = 0.017

CVC, cutaneous verrucous carcinoma; GCA, giant condyloma acuminatum; PEH, pseudoepitheliomatous hyperplasia.