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. 2022 Oct 13;13:938306. doi: 10.3389/fimmu.2022.938306

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Copyright © 2022 Haeger, Kridin, Pieper, Griewahn, Nimmerjahn, Zillikens, König, Ludwig and Hundt

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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FcγRIV inhibition increases total number of neutrophils located at the dermal-epidermal junction (DEJ), but decreases relative numbers of neutrophils at the DEJ. (A) Side view of image stacks (250 x 250 x 90 µm) demonstrating neutrophil extravasation into the dermis in autoantibody transfer-induced EBA of LysM-eGFP mice treated with FcγRIV Ab or isotype control (same groups as in Figure 2 ). (B) Quantification of neutrophils in DEJ vicinity (0-16 µm below DEJ). A significant difference was found between the subgroups on day 8, (p=0.0006). (C) Percentages of neutrophils in DEJ vicinity. A significant difference between the subgroups was found on day 3 (p=0.0088). Subgroups were compared using unpaired t-test revealed. ** <0.05; *** <0.001.