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. 2022 Oct 26;13:6384. doi: 10.1038/s41467-022-34200-0

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — a qPCR expression data for Brwd1 in embryonic day (E) 17.5 forebrain (FB) and adult (6-week) PFC, hippocampus (HIPP) and cerebellum (CER) from euploid vs. Ts65Dn male mice. A.U. = Arbitrary Units, with experimental (non-euploid) group averages normalized to respective euploid controls. b Schematic depicting the generation of mouse genotypes to be investigated. c qPCR expression data for Brwd1 in euploid vs. Brwd1^+/– vs. Ts65Dn vs. Ts65Dn;Brwd1^+/– E17.5 forebrain. d Deficiency of hippocampal LTP in adult male (6-week) Ts65Dn mice is rescued by Brwd1 copy number restoration. The representative traces were recorded at the end of the baseline period (dashed lines) and 60 min after induction of LTP (solid lines). Calibrations: 0.5 mV/5 ms. e Context dependent fear conditioning—displayed as % freezing in the trained context—comparing euploid vs. Brwd1^+/– vs. Ts65Dn vs. Ts65Dn;Brwd1^+/– mice. Data are presented as averages ± SEM. See Supplementary Information Materials for full caption with n’s and statistics. Source data are provided as a source data file.