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. 2022 Oct 26;13:6384. doi: 10.1038/s41467-022-34200-0

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — a Heatmaps of normalized SMARCA2/4 enrichment in euploid vs. Ts65Dn vs. Ts65Dn;Brwd1^+/– adult male (6-week) hippocampus centered (±5 kb) over sites of differential SMARCA2/4 enrichment comparing Ts65Dn vs. euploid mice, separated by genomic context. b Volcano plot depicting regulation of SMARCA2/4 enriched PCGs in euploid animals displaying differential enrichment in Ts65Dn mice; gray circles = unregulated PCGs. Of the PCGs regulated with respect to Smarca2/4 enrichment, 595 are rescued (red circles) in Ts65Dn;Brwd1^+/– mice, whereas the remainder of PCGs do not display such rescue (black circles). c Relative frequency (observed/expected overlap in base pairs) of each chromatin state within significant differentially enriched sites for SMARCA2/4 (Ts65Dn vs. euploid). Chromatin states were obtained from brain regions included in the Roadmap Epigenomics Project. d Bubble plots of GO terms (burgundy) and KEGG pathways (purple) displaying enrichment for rescued differentially enriched PCGs identified in b above. e Odds ratio analysis of overlapping differentially accessible sites in Ts65Dn vs. euploid animals and Ts65Dn;Brwd1^+/– animals, separated by direction of regulation. f Odds ratio analysis of overlapping PCGs displaying rescued differential SMARCA2/4 enrichment in Ts65Dn vs. euploid animals vs. PCGs displaying differential neuronal chromatin accessibility in Ts65Dn vs. euploid mice that are either rescued, or not, in their differential accessibility in Ts65Dn;Brwd1^+/– animals. Insert numbers indicate respective p values for associations, followed by the number of PCGs overlapping per category. See Supplementary Information Materials for full caption with n’s and statistics. Source data are provided as a source data file.