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. 2022 Sep 23;109(10):1742–1760. doi: 10.1016/j.ajhg.2022.09.001

Figure 4.

Figure 4

ExPRS PheWAS and exclusion-ExPRS-PheWAS as an example for continuous traits in MGI

(A) ExPRS PheWAS plot for BMI ExPRS.

(B) Exclusion-ExPRS-PheWAS plot is shown for using BMI ExPRS as predictor among the individuals with normal BMI value (18.5–24.9 kg/m2).

(C) Trait PheWAS plot is shown for BMI trait.

(D) Exclusion-trait-PheWAS plot is shown for using BMI trait as predictor among the individuals with normal BMI value. The axis breaks were chosen so that the ten strongest signals fall in the top scale (y axis breaks for the four panels at −log10(p) are 84, 13, 540, and 12, respectively). The red dashed line indicates genome-wide significance (p < 0.05/1,685), and the orange line indicates nominal significance (p < 0.05).