Figure 2.

Transcriptional profiling and disease specific brain signatures in 16p11.2 transgenic mouse and human neuron models

(A) Overlap among the DEGs observed between mouse brain tissues, peripheral tissues, and human cells.

(B) Overlap among the DEGs observed between NSCs and iNs.

(C) GO enrichment analysis is shown as bar plots for comparisons of mouse brain tissues, human NSCs and iNs. Enrichments at a nominal level and at FDR <0.1 are marked in light blue and blue, respectively.

(D) SynGO enrichment analysis for comparisons of mouse brain tissues, human NSCs, and iNs. Enrichments at nominal level (p < 0.05) and at FDR <0.1 are marked in light blue and blue, respectively.

(E) The pathways enriched for shared mouse brain DEGs.

(F) GO Biological Process terms enriched for DEGs shared between human NSCs and iNs.