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Roles of growth arrest and DNA damage-inducible beta (Gadd45b) in major psychosis. (A) Increased expression of gadd45b in the hippocampal region is detected in schizophrenic mice after intraperitoneal injection of ly379268, which alters the Demethylation of BDNF and Gad67, increasing BDNF and Gad67 activation in large amounts. (B) Decreased Gadd45b, BDNF and Reelin expression in the brain of patients with major psychosis (Figure was created with BioRender.com).
