FIGURE 3.

Roles of growth arrest and DNA damage-inducible beta (Gadd45b) in depression. (A) Increased gadd45b expression in the brain of nucleus accumbens of susceptible mice alters the demethylation of Neurturin, Dlx5, and Ntrk2, resulting in increased Neurturin, Dlx5, and Ntrk2 performance. (B) Increased gadd45b expression in the brains of depressed mice after ect therapy boosts BDNF function by modifying BDNF demethylation. (C) Decreased Gadd45b, BDNF expression in the brain of patients with depression (Figure was created with BioRender.com).