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. 2022 Oct 13;13:996954. doi: 10.3389/fendo.2022.996954

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Copyright © 2022 Subramanian, Tavira, Hofwimmer, Gutsmann, Massier, Abildgaard, Juul, Rydén, Arner and Laurencikiene

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Amount of IL-10 secreting macrophages is increased in scWAT of women with obesity and T2D but not in men. (A) A flow cytometry gating strategy. Selection of alive single cells (four panels on the left), macrophage/monocyte (CD45⁺/CD14⁺) and M1 macrophage (CD45⁺/CD14⁺/CD206⁺/CD11c⁺) selection (two right-side panels). (B) The M1 macrophage population was then analyzed for IL-10 secretion. Representative contour plots from two individuals/group are shown for obese T2D and non-obese healthy women and men. FMO control samples are shown on the left side. (C) Compiled results of IL-10-secreting macrophage populations for non-obese healthy (n=8 for both men and women) and obese T2D (n=7 for women, n=8 for men) men and women from cohort 1. Two-way ANOVA with Tukey’s and Sidak’s multiple comparisons were used in (C) to compare between the groups in men and women and to compare the groups between men and women respectively. *** <0.001, * <0.05.