Table 1.
Clinical parameters of cohort 1.
| Non-obese | Non-obese T2D | Obese T2D | |||||||
|---|---|---|---|---|---|---|---|---|---|
| Women | Men | p-value | Women | Men | p-value | Women | Men | p-value | |
| Sample No | 23 | 22 | 12 | 30 | 9 | 12 | |||
| Age | 57 ± 7 (41 - 69) |
59 ± 7 (43 - 69) |
0.475 | 61 ± 4 (53 - 70) |
*57 - 64 (41 - 69) |
0.950 | 60 ± 5 (51 - 68) |
60 ± 4 (52 - 66) |
0.861 |
| BMI (kg/m2) | 25 ± 2 (22 - 29) |
25 ± 2 (22 - 29) |
0.652 | 26 ± 3 (23 - 30) |
26 ± 2 (23 - 30) |
0.999 | 33 ± 3 (30 - 40) |
*31 - 35 (30 - 43) |
0.986 |
| Fat cell volume (pL) | *407 - 542 (210 - 1295) |
542 ± 100 (368 - 770) |
0.104 | 601 ± 123 (419 - 793) |
551 ± 138 (336 - 900) |
0.290 | 715 ± 128 (526 - 919) |
773 ± 169 (531 -1062) |
0.407 |
| WHR | 0.85 ± 0.05 (0.77 - 0.99) | 0.95 ± 0.05 (0.84 - 1.04) | <0.001 | *0.93 - 1 (0.87 - 1.2) | 0.95 ± 0.04 (0.86 - 1.04) | 0.853 | 0.97 ± 0.03 (0.9 - 1.02) |
1.0 ± 0.04 (0.97 - 1.13) | 0.005 |
| TG (mmol/L) | 1.02 ± 0.33 (0.45 - 1.8) | *0.73 - 1.42 (0.55 - 3.4) | 0.438 | *0.83 - 2.6 (0.3 - 6.8) | *0.77 - 1.6 (0.33 - 3.6) | 0.436 | 1.16 ± 0.48 (0.44 - 2) | 1.7 ± 0.73 (0.73 - 3.1) | 0.041 |
| Fasting insulin (μIU/L) | 4.5 ± 1.2 (2.5 – 6.9) | *4.1 - 9.1 (2.4 - 14.2) |
0.524 | 9.18 ± 6 (0.9 - 19.7) |
*4.3 - 10.8 (2.1 - 24) |
0.007 | *5.2 - 18.3 (4.9 - 33.3) | *7 - 18.5 (1.1 - 67.1) |
0.574 |
| Fasting Glucose (mmol/L) | 5.3 ± 0.3 (4.7 - 5.9) | *5.3 - 5.6 (5.1 - 6.7) |
0.140 | *7.1 - 9.3 (4.9 - 20.2) |
7.4 ± 1.3 (5 - 10.8) |
0.108 | 7.3 ± 0.6 (6.2 - 8.3) |
*6.5 - 11.5 (6.2 - 13.6) |
0.875 |
| HbA1C (mmol/mol) | 36 ± 3 (28 - 44) |
34 ± 4 (24 - 44) |
0.119 | 57 ± 15 (42 - 84) |
47.6 ± 7.7 (34 - 65) |
0.006 | 46 ± 5 (39 - 55) |
55 ± 12 (43 - 76) |
0.037 |
| HOMA-IR | 1.1 ± 0.3 (0.5 - 1.6) |
1.6 ± 0.7 (0.5 - 3.2) |
0.007 | *1.1 – 4.5 (0.35 - 17.7) |
*1.7 - 3.3 (0.5 - 7.4) |
0.679 | 4.2. ± 3.2 (1.3 - 11.4) |
*2.1 – 6.2 (0.67 - 40.6) |
0.641 |
For normally distributed values, the mean ± SD with minimal and maximal values is shown. For non–normally distributed values (indicated with *), median–interquartile range with minimal and maximal values are indicated. Unpaired parametric (t-test) and non-parametric (Mann-Whitney)-tests were used to test the significance between men and women for normally and non-normally distributed (indicated with*) values, respectively. Significant values are indicated in bold.