Table 3.

Comparison of frequencies of the MB-COMT, DRD2, and NR3C1methylation between SCZ patients and controls

Methylation	Genotype	SCZ (n = 110)	Healthy control (n = 100)	Odds ratio	95% confidence interval	pvalue*
MB-COMT	Unmethylation	68 (61.8)	43 (43.0)
	Partial methylation	42 (38.2)	57 (57.0)	0.466	0.268−0.809	0.006*
DRD2	Unmethylation	0 (0.0)	14 (14)
	Partial methylation	110 (100.0)	86 (86)	0.439	0.375−0.514	0.000*
NR3C1	Unmethylation	107 (97.3)	9 (9)
	Partial methylation	3 (2.7)	91 (91)	0.003	0.001−0.011	0.000*

Values are presented as number (%).

SCZ, schizophrenia; MB-COMT, membrane-bound catechol-O-methyltransferase; DRD2, dopamine receptor D2; NR3C1, nuclear receptor subfamily 3 group C member 1.

*Pearson chi-square.