Table 3.

Multivariate analysis examining the individual and interactive effects of baseline leptin levels and the number of physical disorders on the 12-week and 12-month remission

Exposure variable	12-week remission			12-month remission
	Individual effect	Interactive effect		Individual effect	Interactive effect
Leptin (high vs. low)	0.545 (0.415−0.715)‡	0.265 (0.121−0.580)†		1.000 (0.748−1.336)	1.347 (0.536−3.387)
Number of physical disorders (≥ 2 vs. < 2)	1.194 (0.917−1.555)	0.623 (0.289−1.344)		1.007 (0.730−1.390)	1.485 (0.588−3.752)
Leptin × number of physical disorders		0.591 (0.361−0.966)*			1.230 (0.684−2.210)

Values are presented as odds ratio (95% confidence interval).

All data were adjusted for age, sex, education, religious observance, monthly income, body mass index, duration of illness, recurrent depression, EuroQol-5D, and initial antidepressant types.

*p < 0.05; ^†p < 0.01; ^‡p < 0.001.