. 2022 Nov 30;20(4):725–736. doi: 10.9758/cpn.2022.20.4.725

Table 1.

Effect of various agents on prefrontal cortex oxidative stress and inflammation

Groups	Oxidative stress		Inflammation

	GSH	TBARS	IL-10	IL-6	TNF-α
Control	19.21 ± 0.961	4.88 ± 0.342	98.00 ± 4.900	93.70 ± 4.685	43.40 ± 2.170
Nimo D1 per se	18.22 ± 0.922	4.6 ± 0.337	81.50 ± 5.025	82.71 ± 4.524	44.11 ± 2.130
Nimo D2 per se	18.4 ± 0.920	4.81 ± 0.321	100.50 ± 5.101	90.47 ± 4.432	42.60 ± 2.121
Pre-VPA	13.31 ± 0.656^a	12.75 ± 0.893^a	47.50 ± 2.375^a	194.76 ± 9.738^a	122.99 ± 6.150^a
Pre-VPA + Nimo D1	14.85 ± 0.743^b	10.23 ± 0.716^b	77.00 ± 3.850^b	169.07 ± 8.454^b	80.30 ± 4.015^b
Pre-VPA +Nimo D2	17.94 ± 0.897^b	7.33 ± 0.513^b	88.88 ± 4.444^b	125.63 ± 6.282^b	70.56 ± 3.528^b

Results are mean ± standard deviation.

GSH: ^aF_{1, 18} = 163.265 ^bF_{2, 18} = 685.007. TBARS: ^aF_{1, 18} = 1,257.099 ^bF_{2, 18} = 175.039. IL-6 levels: ^aF_{1, 18} = 973.189 ^bF_{2, 18} = 84.89. IL-10 levels: ^aF_{1, 18} = 219.928; ^bF_{2, 18} = 138.116. TNF-α levels: ^aF_{1, 18} = 1,105.281 ^bF_{2, 18} = 364.755.

Pre-VPA, prenatal valproic acid; Nimo, nimodipine; D1, dose 1; D2, dose 2; GSH, glutathione; TBARS, thiobarbituric acid reactive substance; IL, interleukin; TNF, tumor necrosis factor.

Two-way ANOVA followed by Bonferroni’s post-test. ^ap < 0.05 vs. control rats, ^bp < 0.05 vs. Pre-VPA treated rats.