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. 2022 Oct 13;12:975408. doi: 10.3389/fonc.2022.975408

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Copyright © 2022 Deng, Yang, Tian, Liu, Sun and Yang

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Optimization and characterization of encapsulated OX40L mRNA. (A) Structure of the optimized mRNA. Codons in red are optimized. (B) Identification of recombinant plasmid and restriction-digested plasmid by gel electrophoresis 1) 15000 bp marker, 2) 600 ng OX40L-pcDNA3.1 and 3) 200 ng Xba I -digested OX40L-pcDNA3.1. (C) Electrophoretic profile of mRNA 4) 2000 bp marker; 5) 2 ug OX40L-mRNA. (D) Size distribution of OX40L mRNA-LNP. (E) TEM image of OX40L mRNA-LNP (scale bar: 200 nm).