Table 2.

All-cause standardised mortality ratios (SMRs) and excess death rates (EDRs) among persons with multiple sclerosis in Hordaland and Møre and Romsdal counties, Western Norway

	Observed	Expected	SMR (95% CI)	EDR (95% CI)
Sex
Female	535	218.3	2.5* (2.25 to 2.67)	6.1 (5.75 to 6.46)
Male	429	205.4	2.1* (1.90 to 2.30)	7.9 (7.22 to 8.60)
Course of disease
PPMS†	237	92.3	2.6* (2.25 to 2.92)	14.5 (13.24 to 15.60)
RRMS‡	715	327.3	2.2* (2.03 to 2.35)	5.6 (5.28 to 5.98)
Unknown	12	N/A	N/A	N/A
Age at onset
<20	68	17.8	3.8* (2.96 to 4.84)	6.4 (5.77 to 6.86)
20–29	306	102.7	3.0* (2.66 to 3.33)	6.9 (6.47 to 7.25)
30–39	303	134.4	2.3* (2.01 to 2.52)	6.7 (6.04 to 7.24)
40–49	169	93.9	1.8* (1.54 to 2.09)	6.0 (4.78 to 7.05)
≥50	118	74.8	1.6* (1.31 to 1.89)	9.2 (6.03 to 11.79)
Period of onset
<1950	141	63.7	2,2* (1.86 to 2.61)	13.5 (11.52 to 15.22)
1950–1959	116	55.4	2.1* (1.73 to 2.51)	13.6 (11.07 to 15.61)
1960–1969	147	58.6	2.5* (2.12 to 2.95)	12.3 (10.85 to 13.48)
1970–1979	235	72.8	3.2* (2.83 to 3.67)	12.9 (12.13 to 13.61)
1980–1989	187	82.5	2.3* (1.95 to 2.61)	6.3 (5.50 to 6.93)
1990–1999	99	53.3	1.9* (1.51 to 2.26)	2.9 (2.19 to 3.54)
2000–2015	39	36.0	1.1 (0.77 to 1.48)	0.2 (-0.62 to 0.76)
Period of diagnosis
<1980	475	177.5	2.7* (2.44 to 2.93)	15.8 (14.94 to 16.65)
1980–1989	249	97.2	2.6* (2.25 to 2.90)	10.3 (9.39 to 11.03)
1990–1999	152	73.3	2.1* (1.76 to 2.43)	4.4 (3.66 to 4.95)
2000–2019	88	75.7	1.2 (0.93 to 1.43)	0.4 (–0.19 to 0.94)
Total	964	423.6	2.3* (2.13 to 2.42)	6.8 (6.42 to 7.09)

*p < 0.001.

†Primary progressive multiple sclerosis.

‡Relapsing-remitting multiple sclerosis.

EDR, excess death rates; SMR, standardised mortality ratios.