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. 2022 Jul 7;81(11):1556–1563. doi: 10.1136/ard-2022-222858

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© Author(s) (or their employer(s)) 2022. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.

This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/.

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Baseline serum concentrations of IFNα, IFNγ, p40, IL-17F and IL-22 in LOTUS patients and healthy controls and median change from baseline in serum concentrations of IFNγ and p40 through week 24. Each box represents the 25th to 75th percentiles. Lines inside the boxes represent the median. The upper line extends to the largest value ≤1.5 × IQR; the lower line extends to the smallest value ≤1.5 × IQR. Data beyond the end of the lines represents outlier points. **P<0.01, ****p<0.0001. IFN, interferon; IL, interleukin; LLOQ, lower limit of quantification; PBO, placebo; SLE, systemic lupus erythematosus; UST, ustekinumab.