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. 2022 Jul 4;81(11):1515–1523. doi: 10.1136/ard-2022-222608

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© Author(s) (or their employer(s)) 2022. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.

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ASDAS responses at and through week 14. (A) Proportion of patients with ASDAS responses at week 14 was based on NRI-MI analysis. ASDAS low disease activity was defined as ASDAS (CRP) <2.1 and ASDAS inactive disease as ASDAS (CRP) <1.3. (B) Mean change from baseline in ASDAS (CRP) through week 14 was based on MMRM analysis, and the numbers of patients were as observed at each visit. Error bars show 95% CI. Significant in multiplicity-controlled analysis: ***p<0.0001. Without adjustment for multiplicity (nominal): †††p<0.0001. ASDAS, Ankylosing Spondylitis Disease Activity Score; CRP, C-reactive protein; MMRM, mixed-effect model for repeated measures; NRI-MI, non-responder imputation incorporating multiple-imputation; QD, once daily.