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. 2022 Oct 13;13:985911. doi: 10.3389/fimmu.2022.985911

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Copyright © 2022 Chen, Yuan, Liu, Xia, Shi, Su, Wang, Li and Shang

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Internal validation of the robust ECM-APP in the test2 cohort. (A) Sectionalization premised on the median risk score. (B) Survival status and risk score distributions. (C) Heatmap illustrated the expression profiles of 9 genes integrated into the prognostic signature. (D) Survival curve of OS time in low-risk and high-risk subgroups. (E) ROC curve of 1-, 2-, and 3-years of in test2 cohort, area under the curve (AUC) of the curve are 0.771, 0.775, and 0.818, correspondingly. (F) Univariate cox regression analysis showed the independence of risk score, stage, grade, gender, and age. (G) Multivariate cox regression analysis showed the independence of risk score, stage, grade, gender, and age.