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. 2022 Oct 13;15:1038539. doi: 10.3389/fnmol.2022.1038539

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Copyright © 2022 Jia, Liu, Chu, Liu, Mai and Fan.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Expression of genes associated with purinergic signaling in immune cell subpopulations. (A) UMAP plot showing SingleR automatic annotations. Each dot represents one cell. Cells are colored by SingleR annotations. (B) Heatmap showing expression of top 5 marker genes for each immune cell subpopulation annotated by SingleR. Heatmap colors represent relative expression levels. Red represents high expression and blue low expression. Immune cell subpopulations were color-coded above the heatmap. (C) Bubble plot showing expression of purinergic signaling-associated genes in immune cell subpopulations. (D) Bar plot showing differential expression of these genes among immune cell subpopulations (Wilcoxon Rank Sum test; P < 0.01 was considered statistically significant). Genes with log2FC > 0.5 and P < 0.01 are shown.