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. 2022 Oct 13;12:1010188. doi: 10.3389/fonc.2022.1010188

Figure 4.

Figure 4

The effects of BZM on the GBM growth and survival in rats with the intact and the opened BBB: (A) Representative MRI images of GBM in the GBM, GBM+Music, GBM+BZM, and GBM+BZM+Music groups; (B) The MRI analysis of the GBM volume in the GBM, GBM+Music, GBM+BZM, and GBM+BZM+Music groups, the Mann–Whitney–Wilcoxon test, **p<0.01, n=7 in each group; (C) The ICH assay of expression of Ki67 (marker of proliferation) and Bax (marker of apoptosis) in the HG, GBM, GBM+BZM, GBM+Music, and GBM+BZM+Music groups; (D) The quantitative analysis of immunopositive cells (%) expressed Bax and Ki67 in the HG, GBM, GBM+BZM, GBM+Music, and GBM+BZM+Music groups, the Mann–Whitney–Wilcoxon test, **p<0.01, n=7 in each group; (E) Kaplan–Meier overall survival plots in the GBM, GBM+BZM, GBM+Music, and GBM+BZM+Music groups, n=7 in each group. GBM, glioblastoma; BZM, bevacizumab; HG, healthy group.