Table 2.
Plant-derived pharmaceuticals and their uses (Espinosa-Leal et al., 2018).
| Plant-Made Pharmaceutical | Plant | Uses | Manufacturer/notes |
|---|---|---|---|
| ELELYSO™ (taliglucerasealfa) | Carrot or tobacco cell culture | Enzyme replacement | Protalix, Carmiel, Israel and Pfizer, USA, ProCellEx® Stable Expression, First plant-made human recombinant therapeutic protein approved (2014) |
| Vaccine (NDV) | Tobacco suspension cultures | Against Newcastle disease virus | Dow Agrosciences, LLC, Indianapolis, USA, First tobacco cell-based vaccine approved by the FDA against Newcastle disease virus in poultry |
| VEN150 | Rice seeds | For HIV-associated chronic inflammation | Ventria Bioscience, Junction City, KS, USA, Express Tec Stable Expression Scale Cost |
| Moss-GAA | Moss | Pompe disease | Greenovation Biotech GmbH, Heilbronn, Germany Moss Physcomitrella patens-based Broytechnology Speed Scale and Customized |
| Moss-GBA | Moss Nicotianabenthamiana Alfalfa |
Gaucher’s disease; Fabry disease; Influenza, Rabies Rotavirus |
Greenovation Biotech GmbH, Heilbronn, Germany, Moss Physcomitrella patens based Broytechnology, Speed Scale and Customized Medicago, Québec, QC, Canada Proficia™ Transient Expression; Stable Expression |
| Moss-AGAL | |||
| Vaccines | |||
| Antibody | Duckweed leafy biomass | For non-Hodgkin’s lymphoma | Synthon, Nijmegen, The Netherlands, LEX system Stable expression, Speed quality |
| Antibody | Tobacco leaves | HIV | Fraunhofer IME, Aachen, Germany, Stable Nuclear Expression Scale Cost |
| Serum albumin | Rice seed | Healthgen, Wuhan, Hubei, China, Stable Expression, Quality Scale | |
| CaroRx | Tobacco leaves | Dental caries | PlanetBiotechnology, Hayward, CA, USA, Stable Expression Quality Scale |
| PBI-220 | Tobacco leaves | Antibody for anthrax | PlanetBiotechnology, Hayward, CA, USA, Stable Expression Quality Scale |
| DPP4-Fc | Coronavirus infection |