Table 1.
Correlation analysis between RCSD1 and biomarkers of immune cells in LUAD and LUSC based on the TIMER and GEPIA database.
| Description | Gene markers | LUAD | LUSC | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| TIMER | GEPIA | TIMER | GEPIA | ||||||||||
| None | Purity | Tumor | None | Purity | Tumor | ||||||||
| rho | P | rho | P | rho | P | rho | P | rho | P | rho | P | ||
| B cell | CD19 | 0.62 | 4.79e-56 | 0.502 | 7.45e-33 | 0.58 | 1.8e-44 | 0.692 | 1.21e-72 | 0.6 | 5.09e-48 | 0.65 | 8.8e-59 |
| MS4A1 | 0.675 | 0e+00 | 0.565 | 7.22e-43 | 0.66 | 7.3e-62 | 0.735 | 2.39e-86 | 0.663 | 8.52e-62 | 0.72 | 4.9e-78 | |
| CD79A | 0.581 | 0e+00 | 0.463 | 1.46e-27 | 0.54 | 3.8e-38 | 0.693 | 7.26e-73 | 0.596 | 3.60e-47 | 0.67 | 3.1e-65 | |
| CD8+ T Cell | CD8A | 0.663 | 0e+00 | 0.571 | 4.42e-44 | 0.65 | 2.7e-59 | 0.775 | 1.19e-101 | 0.749 | 8.28e-87 | 0.76 | 1.4e-92 |
| CD8B | 0.541 | 0e+00 | 0.454 | 2.21e-26 | 0.53 | 2.7e-36 | 0.604 | 3.26e-51 | 0.604 | 8.66e-49 | 0.59 | 5.7e-47 | |
| IL2RA | 0.675 | 7.22e-70 | 0.604 | 2.38e-50 | 0.66 | 8.9e-63 | 0.792 | 3.73e-109 | 0.745 | 1.98e-85 | 0.77 | 7.1e-98 | |
| Tfh cell | BCL6 | 0.146 | 8.8e-04 | 0.157 | 4.78e-04 | 0.19 | 3.3e-05 | -0.015 | 7.4e-01 | 0.049 | 2.88e-01 | -0.0057 | 0.9 |
| CXCR5 | 0.68 | 0e+00 | 0.575 | 1.09e-44 | 0.17 | 0.00016 | 0.779 | 2.88e-103 | 0.717 | 1.42e-76 | 0.18 | 7.9e-05 | |
| ICOS | 0.753 | 3.07e-95 | 0.665 | 3.68e-64 | 0.74 | 8.1e-86 | 0.837 | 4.6e-133 | 0.79 | 5.29e-103 | 0.82 | 8.2e-121 | |
| Th1 cell | IL12RB1 | 0.813 | 1.16e-122 | 0.752 | 8.63e-91 | 0.81 | 2.2e-112 | 0.898 | 1.51e-180 | 0.871 | 8.41e-149 | 0.89 | 2.8e-164 |
| STAT1 | 0.464 | 0e+00 | 0.378 | 3.77e-18 | 0.45 | 2.4e-25 | 0.522 | 2.33e-36 | 0.493 | 1.57e-30 | 0.49 | 4e-30 | |
| CCR5 | 0.811 | 0e+00 | 0.749 | 9.07e-90 | 0.8 | 4.4e-111 | 0.887 | 2.12e-169 | 0.858 | 2.93e-139 | 0.88 | 2.9e-156 | |
| Th2 cell | CCR4 | 0.769 | 0e+00 | 0.721 | 2.90e-80 | 0.78 | 3.2e-99 | 0.875 | 1.3e-159 | 0.84 | 4.08e-128 | 0.88 | 5.8e-157 |
| STAT6 | 0.227 | 2.03e-07 | 0.293 | 3.04e-11 | 0.24 | 7.1e-08 | 0.156 | 4.63e-04 | 0.18 | 7.82e-05 | 0.11 | 0.013 | |
| HAVCR1 | 0.042 | 3.46e-01 | 0.061 | 1.76e-01 | 0.093 | 0.04 | 0.368 | 1.66e-17 | 0.378 | 1.22e-17 | 0.35 | 3.9e-15 | |
| Th17 cell | IL21R | 0.754 | 0e+00 | 0.67 | 1.67e-65 | 0.75 | 4.5e-88 | 0.855 | 3.15e-144 | 0.813 | 1.24e-113 | 0.84 | 8.6e-131 |
| IL23R | 0.44 | 9.02e-26 | 0.42 | 1.87e-22 | 0.47 | 2e-28 | 0.404 | 4.27e-21 | 0.336 | 4.74e-14 | 0.37 | 2e-17 | |
| CCR6 | 0.717 | 0e+00 | 0.641 | 2.03e-58 | 0.71 | 7.1e-75 | 0.815 | 1.51e-120 | 0.746 | 7.90e-86 | 0.8 | 5.4e-109 | |
| Treg cell | STAT5B | 0.522 | 2.47e-37 | 0.559 | 6.72e-52 | 0.47 | 4.4e-28 | 0.271 | 7.49e-10 | 0.321 | 7.23e-13 | 0.19 | 1.7e-05 |
| NT5E | 0.159 | 2.95e-04 | 0.143 | 1.51e-03 | 0.15 | 0.00078 | 0.217 | 9.27e-07 | 0.118 | 9.82e-03 | 0.2 | 8.6e-06 | |
| CCR8 | 0.707 | 2.34e-79 | 0.633 | 1.22e-56 | 0.7 | 1.3e-71 | 0.791 | 1.25e-108 | 0.743 | 1.01e-84 | 0.77 | 8.4e-97 | |
| IL7R | 0.793 | 0e+00 | 0.733 | 3.25e-84 | 0.8 | 2.3e-108 | 0.668 | 5.57e-66 | 0.573 | 6.18e-43 | 0.65 | 2.3e-59 | |
| T cell exhaustion | PDCD1 | 0.629 | 4.93e-58 | 0.532 | 2.04e-37 | 0.62 | 5.5e-52 | 0.791 | 1.9e-108 | 0.748 | 1.22e-86 | 0.78 | 1.1e-99 |
| CTLA4 | 0.681 | 0e+00 | 0.576 | 6.51e-45 | 0.68 | 9.1e-66 | 0.795 | 2.23e-110 | 0.737 | 6.27e-83 | 0.79 | 1.4e-109 | |
| LAG3 | 0.506 | 0e+00 | 0.402 | 1.50e-20 | 0.47 | 3.1e-28 | 0.665 | 3e-65 | 0.63 | 4.15e-54 | 0.61 | 8e-51 | |
| GZMB | 0.435 | 3.56e-25 | 0.303 | 5.94e-12 | 0.39 | 2.4e-19 | 0.644 | 5.23e-60 | 0.571 | 1.51e-42 | 0.61 | 5e-50 | |
| M1 Macrophage | NOS2 | 0.315 | 2.46e-13 | 0.246 | 3.30e-08 | 0.34 | 3.8e-14 | 0.115 | 1e-02 | 0.148 | 1.17e-03 | 0.098 | 0.031 |
| IRF5 | 0.451 | 0e+00 | 0.363 | 8.37e-17 | 0.43 | 6.7e-23 | 0.214 | 1.31e-06 | 0.193 | 2.15e-05 | 0.17 | 0.00022 | |
| PTGS2 | -0.099 | 2.43e-02 | -0.115 | 1.09e-02 | -0.1 | 0.023 | 0.047 | 0.296 | -0.048 | 2.96e-01 | 0.045 | 0.32 | |
| M2 Macrophage | CD163 | 0.666 | 0e+00 | 0.604 | 1.94e-50 | 0.62 | 2.6e-52 | 0.78 | 9.63e-104 | 0.73 | 1.10e-80 | 0.76 | 1.1e-92 |
| MRC1 | 0.611 | 0e+00 | 0.557 | 1.63e-41 | 0.62 | 6.1e-53 | 0.703 | 9.08e-76 | 0.642 | 1.14e-56 | 0.69 | 2.6e-70 | |
| CD209 | 0.625 | 0e+00 | 0.551 | 1.58e-40 | 0.63 | 3.3e-54 | 0.634 | 1.25e-57 | 0.571 | 1.11e-42 | 0.62 | 5.2e-53 | |
| MS4A4A | 0.672 | 0e+00 | 0.6 | 1.31e-49 | 0.68 | 4.4e-66 | 0.793 | 2.1e-109 | 0.743 | 5.48e-85 | 0.78 | 7.4e-100 | |
| TAM | CCL2 | 0.374 | 0e+00 | 0.253 | 1.26e-08 | 0.37 | 5.1e-17 | 0.57 | 1.38e-44 | 0.501 | 1.26e-31 | 0.55 | 8.2e-40 |
| CD68 | 0.599 | 0e+00 | 0.528 | 8.61e-37 | 0.59 | 1.1e-46 | 0.665 | 2.44e-65 | 0.586 | 2.32e-45 | 0.62 | 2.2e-52 | |
| IL10 | 0.615 | 6.19e-55 | 0.518 | 3.08e-35 | 0.6 | 3.6e-49 | 0.644 | 4.31e-60 | 0.589 | 7.11e-46 | 0.63 | 5.6e-56 | |
| Monocyte | CD14 | 0.573 | 0e+00 | 0.484 | 2.81e-30 | 0.57 | 9.3e-43 | 0.76 | 1.29e-95 | 0.681 | 2.32e-66 | 0.74 | 7.9e-85 |
| CD33 | 0.657 | 0e+00 | 0.582 | 4.54e-46 | 0.63 | 1.2e-54 | 0.809 | 2.29e-117 | 0.755 | 4.63e-89 | 0.78 | 1.2e-102 | |
| ITGAX | 0.656 | 1.08e-64 | 0.569 | 1.49e-43 | 0.62 | 1.6e-52 | 0.777 | 3.18e-102 | 0.703 | 2.56e-72 | 0.71 | 6.6e-76 | |
| Natural killer cell | B3GAT1 | 0.259 | 2.31e-09 | 0.23 | 2.51e-07 | 0.28 | 4.3e-10 | 0.58 | 1.87e-46 | 0.545 | 3.28e-38 | 0.58 | 1.5e-44 |
| KIR3DL1 | 0.286 | 3.49e-11 | 0.226 | 3.79e-07 | 0.32 | 9.2e-13 | 0.486 | 4.96e-31 | 0.45 | 3.25e-25 | 0.5 | 4e-32 | |
| CD7 | 0.484 | 0e+00 | 0.375 | 6.61e-18 | 0.47 | 2.6e-27 | 0.755 | 2.03e-93 | 0.688 | 3.17e-68 | 0.74 | 6e-86 | |
| Neutrophils | FCGR3A | 0.601 | 0e+00 | 0.523 | 5.15e-36 | 0.6 | 2.3e-48 | 0.785 | 8.73e-106 | 0.74 | 5.81e-84 | 0.77 | 1.5e-95 |
| CCR7 | 0.755 | 0e+00 | 0.669 | 2.33e-65 | 0.75 | 2.9e-89 | 0.802 | 8.83e-114 | 0.747 | 2.44e-86 | 0.79 | 3e-106 | |
| CD55 | -0.081 | 6.66e-02 | -0.063 | 1.65e-01 | -0.068 | 0.13 | 0.242 | 4.05e-08 | 0.176 | 1.09e-04 | 0.21 | 4.2e-06 | |
| ITGAM | 0.632 | 0e+00 | 0.565 | 6.15e-43 | 0.65 | 4.6e-59 | 0.721 | 1.5e-81 | 0.652 | 4.95e-59 | 0.72 | 3.2e-78 | |
| Dendritic cell | CD1C | 0.467 | 2.77e-29 | 0.394 | 8.39e-20 | 0.47 | 2.4e-27 | 0.61 | 2.61e-52 | 0.475 | 3.29e-28 | 0.59 | 3e-47 |
| THBD | 0.395 | 1.1e-20 | 0.317 | 6.08e-13 | 0.43 | 3.8e-23 | -0.021 | 6.36e-01 | -0.089 | 5.09e-02 | -0.012 | 0.8 | |
| NRP1 | 0.281 | 1.01e-10 | 0.268 | 1.48e-09 | 0.28 | 3.6e-10 | 0.531 | 9.68e-38 | 0.444 | 1.70e-24 | 0.49 | 7.2e-31 | |
Bold values indicate P < 0.05.