TABLE 3.
Standardized mortality ratios (SMRs) of fatal HD among patients with sarcoma by histology and chemotherapy status.
|
Histology |
Patients without chemotherapy |
Patients with chemotherapy |
||||||||
| No. of deaths | No. of patients | Person-years | Mortality1 | SMR (95% CI) | No. of deaths | No. of patients | Person-years | Mortality1 | SMR (95% CI) | |
| Ewing sarcoma | 3 | 241 | 1,796 | 167.0 | 5.12 (1.65–15.87) | 14 | 2,814 | 19,634 | 71.3 | 5.52 (3.27–9.31) |
| Osteosarcoma | 45 | 1,683 | 11,899 | 378.2 | 1.49 (1.11–1.99) | 38 | 4,821 | 34,654 | 109.7 | 2.93 (2.13–4.02) |
| Synovial sarcoma | 33 | 1,797 | 14,677 | 224.8 | 1.51 (1.08–2.13) | 9 | 1,374 | 8,504 | 105.8 | 1.69 (0.88–3.25) |
| MPNST | 57 | 1,591 | 9,338 | 610.4 | 1.47 (1.33–1.90) | 7 | 525 | 2,037 | 343.7 | 3.59 (1.71–7.52) |
| Chondrosarcoma | 225 | 5,352 | 47,285 | 475.8 | 1.38 (1.21–1.57) | 7 | 589 | 2,944 | 237.8 | 1.10 (0.52–2.30) |
| MFH | 716 | 6,973 | 56,245 | 1,273.0 | 1.33 (1.24–1.43) | 59 | 1,519 | 9,845 | 599.3 | 1.41 (1.09–1.82) |
| Fibrosarcoma | 177 | 3,613 | 27,338 | 647.4 | 1.27 (1.10–1.48) | 8 | 489 | 2,500 | 320.0 | 1.28 (0.64–2.56) |
| Liposarcoma | 600 | 9,735 | 75,766 | 791.9 | 1.26 (1.16–1.36) | 23 | 1,084 | 6,129 | 375.3 | 1.25 (0.83–1.88) |
| Leiomyosarcoma | 314 | 5,997 | 36,725 | 855.0 | 1.17 (1.05–1.31) | 24 | 1,535 | 5,214 | 460.3 | 1.30 (0.87–1.94) |
| Chordoma | 54 | 1,532 | 9,782 | 552.0 | 1.06 (0.81–1.39) | 1 | 73 | 366 | 273.3 | 0.66 (0.09–4.67) |
| Others | 835 | 18,694 | 104,478 | 799.2 | 1.56 (1.46–1.67) | 101 | 8,874 | 43,136 | 234.1 | 1.80 (1.48–2.18) |
SMR, standardized mortality ratio; HD, heart diseases; MFH, Malignant fibrohistiocytoma; MPNST, Malignant Peripheral Nerve Sheath Tumor.
1Per 100,000 person-years.