TABLE 4.
Fatal HD among patients with sarcoma by histological subtypes and years since diagnosis.
|
Histology |
Time since diagnosis |
|||
| 0–1 Year | 1–5 Years | 5–10 Years | >10 Years | |
| All | ||||
| No. of deaths | 675 | 1016 | 720 | 939 |
| Person-years | 69,322 | 181,220 | 130,829 | 154,069 |
| SMR1 | 1.31 | 0.94 | 1.32 | 2.85 |
| 95%CI | 1.21–1.41 | 0.89–1.00 | 1.22–1.42 | 2.68–3.04 |
| Chondrosarcoma | ||||
| No. of deaths | 27 | 73 | 38 | 94 |
| Person-years | 5,388 | 16,056 | 12,997 | 16,202 |
| SMR | 0.9 | 1.05 | 0.92 | 2.98 |
| 95%CI | 0.62–1.31 | 0.84–1.33 | 0.67–1.27 | 2.44–3.65 |
| Chordoma | ||||
| No. of deaths | 9 | 16 | 17 | 13 |
| Person-years | 1,458 | 4,184 | 2,643 | 1,973 |
| SMR | 0.84 | 0.61 | 1.48 | 2.77 |
| 95%CI | 0.44–1.62 | 0.37–0.99 | 0.92–2.38 | 1.61–4.78 |
| Ewing sarcoma | ||||
| No. of deaths | 1 | 4 | 3 | 9 |
| Person-years | 2,804 | 7,044 | 4,947 | 6,844 |
| SMR | 1.28 | 3.42 | 4.81 | 15.16 |
| 95%CI | 0.18–9.09 | 1.28–9.11 | 1.55–14.91 | 7.89–29.13 |
| Fibrosarcoma | ||||
| No. of deaths | 33 | 62 | 38 | 52 |
| Person-years | 3,685 | 10,331 | 7,218 | 8,885 |
| SMR | 1.1 | 0.91 | 1.17 | 3.12 |
| 95%CI | 0.78–1.54 | 0.71–1.17 | 0.85–1.61 | 2.38–4.1 |
| Leiomyosarcoma | ||||
| No. of deaths | 72 | 115 | 77 | 74 |
| Person-years | 6,450 | 16,327 | 10,387 | 9,252 |
| SMR | 1.13 | 0.86 | 1.25 | 2.33 |
| 95%CI | 0.89–1.42 | 0.72–1.03 | 1.00–1.57 | 1.86–2.93 |
| Liposarcoma | ||||
| No. of deaths | 72 | 153 | 162 | 236 |
| Person-years | 9,812 | 28,926 | 21,418 | 22,498 |
| SMR | 0.88 | 0.73 | 1.28 | 2.89 |
| 95%CI | 0.70–1.11 | 0.62–0.85 | 1.10–1.49 | 2.54–3.28 |
| MFH | ||||
| No. of deaths | 120 | 250 | 184 | 221 |
| Person-years | 7,472 | 20,681 | 16,734 | 21,766 |
| SMR | 1.06 | 0.99 | 1.35 | 2.60 |
| 95%CI | 0.89–1.27 | 0.87–1.12 | 1.17–1.56 | 2.28–2.97 |
| MPNST | ||||
| No. of deaths | 14 | 19 | 12 | 19 |
| Person-years | 1,805 | 4,148 | 2,872 | 2,677 |
| SMR | 1.62 | 1.02 | 1.32 | 3.8 |
| 95%CI | 0.96–2.74 | 0.65–1.60 | 0.75–2.32 | 2.43–5.96 |
| Osteosarcoma | ||||
| No. of deaths | 20 | 15 | 12 | 36 |
| Person-years | 5,743 | 14,378 | 10,884 | 15,972 |
| SMR | 1.73 | 0.96 | 1.33 | 4.75 |
| 95%CI | 1.12–2.69 | 0.58–1.59 | 0.76–2.35 | 3.43–6.59 |
| Synovial sarcoma | ||||
| No. of deaths | 8 | 10 | 7 | 17 |
| Person-years | 2,872 | 7,842 | 5,681 | 7,005 |
| SMR | 1.46 | 0.93 | 1.12 | 3.35 |
| 95%CI | 0.73–2.91 | 0.50–1.74 | 0.53–2.35 | 2.08–5.39 |
| Others | ||||
| No. of deaths | 299 | 299 | 170 | 168 |
| Person-years | 21,827 | 51,298 | 35,044 | 40,989 |
| SMR | 1.87 | 1.12 | 1.51 | 2.82 |
| 95%CI | 1.67–2.09 | 1.00–1.25 | 1.30–1.76 | 2.43–3.28 |
SMR, standardized mortality ratio; MFH, Malignant fibrohistiocytoma; MPNST, Malignant Peripheral Nerve Sheath Tumor; NOS, not of specific.
1Reference population: general US population, 1969 to 2016. Adjusted to the age, sex and race distributions between patients and the general population.