TABLE 6.

Subgroup analysis of fatal HD among patients with sarcoma by histology and clinical stage.

Histology	Clinical stage	HR1	95% CI	P-value
Ewing sarcoma
	All	0.97	0.85–1.11	0.659
	Localized	Inf	0.00 – Inf	0.999
	Regional	0.04	0.01–0.29	0.001
	Distant	0.00	0.00 – Inf	1.000
Osteosarcoma
	All	0.97	0.85–1.11	0.659
	Localized	3.18	1.24–8.13	0.016
	Regional	0.63	0.28–1.40	0.259
	Distant	0.25	0.06–1.03	0.055
Synovial sarcoma
	All	0.97	0.85–1.11	0.659
	Localized	0.40	0.06–2.86	0.363
	Regional	3.06	0.85–11.11	0.088
	Distant	Inf	0.00–Inf	1.000
MPNST
	All	0.97	0.85–1.11	0.659
	Localized	4.59	0.85–24.67	0.076
	Regional	0.71	0.05–10.57	0.804
	Distant	0.87	0.18–4.24	0.867
Chondrosarcoma
	All	0.97	0.85–1.11	0.659
	Localized	0.44	0.10–1.87	0.268
	Regional	1.05	0.30–3.60	0.949
	Distant	0.52	0.10–2.81	0.449
MFH
	All	0.97	0.85–1.11	0.659
	Localized	1.17	0.83–1.65	0.375
	Regional	0.89	0.51–1.53	0.667
	Distant	0.28	0.07–1.16	0.079
Fibrosarcoma
	All	0.97	0.85–1.11	0.659
	Localized	0.94	0.36–2.47	0.902
	Regional	1.76	0.38–8.23	0.474
	Distant	1.06	0.06–18.89	0.968
Liposarcoma
	All	0.97	0.85–1.11	0.659
	Localized	0.84	0.48–1.45	0.523
	Regional	1.33	0.54–3.23	0.534
	Distant	0.49	0.06–3.94	0.504
Leiomyosarcoma
	All	0.97	0.85–1.11	0.659
	Localized	0.83	0.39–1.77	0.635
	Regional	1.31	0.57–2.97	0.524
	Distant	0.44	0.14–1.39	0.162
Chordoma
	All	0.97	0.85–1.11	0.659
	Localized	1.66	0.16–17.36	0.673
	Regional	0.00	0.00 – Inf	0.998
	Distant	0.00	0.00 – Inf	1.000
Others
	All	0.97	0.85–1.11	0.659
	Localized	0.97	0.70–1.34	0.848
	Regional	0.76	0.46–1.24	0.273
	Distant	0.47	0.29–0.77	0.003

HD, heart diseases; HR, hazard ratio; MFH, malignant fibrohistiocytoma; MPNST, Malignant Peripheral Nerve Sheath Tumor.

¹We performed a survival analysis using a Cox proportional hazards model to calculate hazard ratios (HRs), adjusting for demographics: age, sex, race, year of diagnosis, socioeconomic status, insurance status and tumor characteristics: clinical stage, grade at presentation, radiotherapy and surgery status.