TABLE 3.

Zebrafish models of tauopathy.

Study	Method(s)	Target of tau phosphorylation	NFT formation	Other phenotype
Bai et al., 2007	MAP-Tau4R mutation	Enolase-2 promoter – Neurons	Yes
Cosacak et al., 2017	Tau P301L mutation	her4.1 promoter – NPCs (with radial glial identity) and neurons	No – Investigated in adult zebrafish
Lopez et al., 2017	Tau A152T mutation	PanN:Gal4VP15 driver – Pan-neuronal	Yes	Increased neuronal cell death. Impaired proteasome function.
Paquet et al., 2009	Tau P301L mutation	HuC promoter – Neurons	Yes	Increased neuronal cell death. Reduced length and branching of motor neurons.
Tomasiewicz et al., 2002	FTDP-17 mutation	GATA-2 promoter – Neurons	Yes	Disruption of cytoskeletal filaments in cell axon