TABLE 4.

Zebrafish models of Aβ toxicity.

Study	Method(s)	Aβ aggregation	Neuronal cell death	NSPC proliferation and neurogenesis	Other phenotype
Bhattarai et al., 2016	Human Aβ 42 (ventricular injections)	Yes	Yes	Yes	Formation of intracellular Aβ-sheets. Impaired conditioning and reduced learned anxiety response
Bhattarai et al., 2017	Human TR-Aβ 42 (ventricular injections)	Yes	Yes	Yes	Increased microglia activation. Increased synaptic degeneration.
Nery et al., 2014	Aβ 1–42 (ventricular injections)	Not reported	Yes – But also observed in vehicle injected groups (compared to non-injected controls)	Not reported	Increased tau phosphorylation. Impaired avoidance of aversive stimulus.
Newman et al., 2010	Human Aβ 42 (expression in melanophores under mitfa promoter)	Not reported	Not reported	Not reported	Abnormal pattern and loss of skin pigmentation