Table. Baseline Participant Characteristics.
| Characteristic | Mean (SE) | |||
|---|---|---|---|---|
| Kisspeptin-placebo order | Placebo-kisspeptin order | |||
| Demographics | ||||
| Age, y | 30.4 (1.4) | 27.9 (1.9) | ||
| BMI | 23.5 (0.8) | 22.8 (0.6) | ||
| Race or ethnicity, No. (% of group) | ||||
| Asian | 2 (13) | 1 (6) | ||
| Black | 2 (13) | 0 | ||
| Hispanic | 0 | 2 (13) | ||
| White | 12 (75) | 13 (81) | ||
| Sexual history | ||||
| Age of partner, y | 31.6 (2.0) | 29.8 (2.2) | ||
| Duration of relationship, mo | 72.1 (10.2) | 51.1 (10.7) | ||
| Intercourse per month | 2.3 (0.4) | 2.8 (0.4) | ||
| Duration of distressing low sexual desire (months) | 45.6 (8.9) | 37.6 (7.8) | ||
| FSFIa | ||||
| Total (range, 2.0-36.0) | 16.8 (1.7) | 19.4 (1.2) | ||
| Desire domain (range, 1.2-6.0) | 1.6 (0.1) | 2.0 (0.2) | ||
| FSDS-DAOb | ||||
| Total (range, 0-60) | 41.1 (2.1) | 38.3 (2.1) | ||
| Item 13 (range, 0-4) | 3.5 (0.2) | 3.6 (0.1) | ||
| Depression and anxiety questionnaires | ||||
| PHQ-9 (range, 0-27)c | 2.8 (0.7) | 1.8 (0.4) | ||
| GAD-7 (range, 0-21)d | 2.9 (0.6) | 2.3 (0.6) | ||
| Reproductive hormones | Kisspeptin visit | Placebo visit | Kisspeptin visit | Placebo visit |
| Kisspeptin, pmol/L | 15.1 (2.1) | 14.2 (2.3) | 10.3 (1.4) | 16.4 (2.4) |
| Luteinizing hormone, IU/L | 4.4 (0.8) | 4.6 (0.9) | 4.5 (0.8) | 4.0 (0.5) |
| Follicle stimulating hormone, IU/L | 5.1 (0.6) | 4.5 (0.4) | 4.9 (0.5) | 4.7 (0.4) |
| Estradiol, pmol/L | 150 (36.8) | 172 (37.8) | 175.1 (29.8) | 201.6 (46.1) |
| Progesterone, nmol/L | 1.9 (0.6) | 3.3 (1.2) | 3.1 (1.3) | 1.4 (0.3) |
| Testosterone, nmol/L | 1.0 (0.1) | 1.0 (0.1) | 1.0 (0.1) | 1.0 (0.1) |
Abbreviations: BMI, body mass index (calculated as weight in kilograms divided by height in meters squared); FSFI, Female Sexual Function Index; GAD-7, Generalized Anxiety Disorder Assessment; PHQ-9, Patient Health Questionnaire.
a
Total FSFI scores of 26.0 or lower indicate sexual dysfunction; scores on the desire domain of 5.0 or lower indicate low desire.
b
High total FSDS-DAO scores indicate high distress; high scores on item 13 denote participants experiencing higher levels of bother by low sexual desire.
c
PHQ-9 scores of 5 or higher indicate depression.
d
GAD-7 scores of 5 or higher indicate anxiety.