Table 1.
Heatmap comparison of VLP cell binding inhibition assay to the inhibition of soluble spike protein binding to ACE2 positive cells and authentic virus neutralization. Data of authentic virus neutralization and binding of trimeric spike protein to ACE2 positive cells were taken from Bertoglio et al. [31] for comparison. Color code: From dark green to yellow to dark red = from the highest neutralization potential to the lowest potential in the respective assay.
| Antibody Clone | Neutralization of Authentic SARS-CoV-2 Virus (Plaque Assay) [31] | Trimeric Spike Protein Cell Binding Inhibition [31] | VLP Cell Binding Inhibition Assay |
|---|---|---|---|
| STE90-D7 | 0.00 | 0.33 | −0.16 |
| STE94-B2 | 0.06 | 0.57 | 0.30 |
| STE90-B2-C5 | 0.13 | 0.59 | 0,07 |
| STE91-C4 | 0.14 | 0.75 | 0.15 |
| STE90-B3-B10 | 0.18 | 0.65 | 0.13 |
| STE90-B2-B3 | 0.22 | 0.36 | −0.01 |
| STE90-B2-A1 | 0.25 | 0.59 | 0.51 |
| STE94-A1 | 0.32 | 0.58 | 0.21 |
| STE94-B1-E12 | 0.50 | 0.88 | 0.68 |
| STE94-F12 | 0.65 | 0.82 | 0.54 |
| STE90-B2-D12 | 0.89 | 0.92 | 0.80 |
| STE90-C11 | 0.98 | 0.98 | 0.95 |