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. 2022 Oct 10;14(10):2156. doi: 10.3390/pharmaceutics14102156

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© 2022 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Representative MR T₁ × T₂ reconstruction of the thrombus (2 h vs. 24 h incubation time) introduced through the right external carotid artery up to the intracranial internal carotid artery bifurcation to occlude the MCA rat brain. Clots were immersed in (A) PBS, (B) NP, or (C) KCREKA-NP solutions before MCA occlusion in order to assess the signal variation due to the age of the thrombus. Thrombus signal intensity changes (T₁-wi, T₂-wi, and T₁ × T₂) are plotted over incubation time for the three immersed solutions—(D) PBS, (E) NP, and (F) KCREKA-NP. ** p < 0.01, using one way ANOVA followed by Kruskal-Wallis test.