Table 3.
Concentrations of relevant cytokines in amniotic fluid according to symptomatic status at birth and severity (median and interquartile).
| Uninfected Fetuses n = 40 |
Infected Fetuses n = 40 | Asymptomatic Infected Fetuses n = 9 | Symptomatic Infected Fetuses n = 31 |
Symptomatic Non-Severe Infected Fetuses n = 13 |
Symptomatic and Severe infected Fetuses n = 18 |
p-Value * | p-Value ** | |
|---|---|---|---|---|---|---|---|---|
| IP10 internal | 135.945 (54.1875; 272.7225) | 451.405 (79.335; 956.49) | 118.04 (49.58; 605.312) | 505.33 (84.27; 1342.97) | 717.53 (84.06; 1170.79) | 315.52 (84.9775; 1419.735) | 0.0037 | 0.0006 |
| MCP1 internal | 0 (0; 2.39) | 0.375 (0; 5.415) | 0 (0; 2.57) | 0.75 (0; 5.52) | 0.75 (0; 3.66) | 2.13 (0; 9.1625) | 0.0636 | 0.0156 |
| MIG internal | 0 (0; 9.7825) | 0.975 (0; 17.695) | 0 (0; 0) | 3.7 (0; 18.655) | 1.05 (0; 17.49) | 10.05 (0; 18.8275) | 0.1480 | 0.0309 |
| RANTES internal | 0 (0; 1.8625) | 1.65 (0; 5.65) | 0 (0; 2.89) | 2.08 (0; 6.29) | 0 (0; 1.58) | 5.505 (1.81; 11.0875) | 0.0585 | 0.0046 |
| IP10 surface | 216.47 (71.6525; 393.6525) | 775.625 (300.34; 1680.205) | 264.38 (181.94; 704.448) | 892.91 (587.435; 2036.44) | 740.69 (566.94; 892.91) | 1374.01 (629.18; 3813.8825) | 0.0138 | 0.0005 |
| CRP surface | 2993.57 (1885.88; 5824.6725) | 3253.165 (2054.605; 6279.77) | 2893.28 (1733.97; 3241.92) | 3319.65 (2095.535; 7397.78) | 2121.79 (1816.45; 3264.41) | 6068.58 (3347.9625; 14,867.88) | 0.1388 | 0.0035 |
| TRAIL surface | 77.8392 (36.0268; 216.2042) | 90.6635 (21.82125; 218.6225) | 25.688 (7.6784; 101.64) | 125.625 (27.66375; 229.949) | 89.695 (21.015; 133.802) | 220.6135 (62.4187; 410.7662) | 0.3280 | 0.0302 |
| IL18 soluble | 4.206 (3.099; 7.05) | 7.416 (4.29; 10.698) | 6.48 (4.8; 9.24) | 8.124 (4.26; 11.562) | 5.16 (4.2; 7.2) | 10.308 (7.395; 11.85) | 0.0234 | 0.0060 |
| IP10 soluble | 10,852.986 (7354.974; 15,979.596) | 24,155.274 (13,671.278; 33,171.693) | 13,415.432 (7824.636; 28,769.988) | 24,195.876 (16,469.694; 36,399.324) | 27,967.932 (18,816.576; 39,577.848) | 24,155.274 (15,166.275; 28,695.609) | 0.0000 | 0.0001 |
| CRP soluble | 725.232 (196.254; 1356.666) | 757.836 (352.305; 2831.577) | 646.2 (356.676; 772.752) | 898.992 (374.388; 2997.594) | 699.528 (168.756; 898.992) | 2841.414 (675.408; 7620.282) | 0.0987 | 0.0044 |
| TRAIL soluble | 180.4938 (98.5061; 346.6263) | 299.2086 (141.0222; 802.9308) | 174.888 (141.1776; 224.6172) | 415.3464 (155.9106; 888.8652) | 245.2572 (140.556; 509.3052) | 589.3542 (219.0777; 1095.1194) | 0.0123 | 0.0004 |
* infected vs. uninfected fetuses; ** symptomatic vs. asymptomatic fetuses.