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. 2022 Oct 7;14(10):2204. doi: 10.3390/v14102204

Figure 1.

Figure 1

MCPyV genome and T antigens. (A) Circularized MCPyV viral genome depicting NCCR, early genes (ST, 57kD, LT, ALTO), late genes (VP1, VP2) and the microRNA miR-m1. Abbreviations: ST—small tumor antigen, 57kD—57 kD tumor antigen, LT—large tumor antigen, ALTO—alternative large tumor open reading frame, NCCR—non-coding control region, ori—origin of replication, VP—viral protein. (B) Functional domains of MCPyV T antigens, including DnaJ (light blue), LXCXE (indigo), and Zn finger binding domain (orange). Numbers indicate amino acid position as described in Wendzicki et al. [71]. Truncating mutation locations are indicated by red bar. Abbreviations: LSD (purple)—LT stabilizing domain, MUR (yellow)—MCPyV unique region, NLS (silver)—nuclear localization signal, OBD (red)—origin binding domain.