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. 2022 Oct 21;14(10):722. doi: 10.3390/toxins14100722

Table 2.

The origin, primary structure, secondary structure, length, and antibacterial activity of brevinins. Secondary structure prediction was performed by GOR IV algorithm (https://npsa-prabi.ibcp.fr/cgi-bin/npsa_automat.pl?page=/NPSA/npsa_gor4.html accessed on 27 September 2022); Hh: Alpha helix; Ee: Extended strand; Cc: Random coil; MIC: Minimum inhibitory concentrations (μM); NA: not active.

Peptides Name Species Primary Structure Secondary Structure Length MIC (μM) Ref.
Brevinin-1 Rana brevipoda porsa FLPVLAGIAAKVVPALFCKITKKC Hh: 33.33%
Ee: 16.67%
Cc: 50.00%		 24 34 (E. coli)
8 (S. aureus)		 [48]
Brevinin-1GHd Hylarana guentheri FLGALFKVASKLVPAAICSISKKC Hh: 16.67%
Ee: 37.50%
Cc: 45.83%		 24 8 (E. coli)
32 (P. aeruginosa)
2 (S. aureus)
4 (MRSA)
4 (C. albicans)		 [58]
Brevinin-1AUa Rana aurora aurora FLPILAGLAAKLVPKVFCSITKKC Hh: 12.50%
Ee: 33.33%
Cc: 54.17%		 24 13 (E. coli)
25 (P. aeruginosa)
13 (E. cloacae)
50 (K. pneumoniae)
3 (S. aureus)
6 (S. epidermidis)
3 (C. albicans)		 [59]
Brevinin-1AUb FLPILAGLAANILPKVFCSITKKC Ee: 33.33%
Cc: 66.67%		 24 25 (E. coli)
25 (P. aeruginosa)
25 (E. cloacae)
>50 (K. pneumoniae)
3 (S. aureus)
6 (S. epidermidis)
3 (C. albicans)
Brevinin-1BYa Rana boylii FLPILASLAAKFGPKLFCLVTKKC Hh: 16.67%
Ee: 33.33%
Cc: 50.00%		 24 17 (E. coli)
2 (S. aureus)
3 (C. albicans)		 [50]
Brevinin-1BYb LPILASLAAKLGPKLFCLVTKKC Hh: 13.04%
Ee: 30.43%
Cc: 56.52%		 23 16 (E. coli)
4 (S. aureus)
16 (C. albicans)
Brevinin-1BYc LPILASLAATLGPKLLCLITKKC Ee: 39.13%
Cc: 60.87%		 23 NA (E. coli)
8 (S. aureus)
35 (C. albicans)
Brevinin-1SY Rana sylvatica FLPVVAGLAAKVLPSIICAVTKKC Ee: 41.67%
Cc: 58.33%		 24 45 (E. coli)
7 (S. aureus)		 [51]
Brevinin-1LTa Hylarana latouchii FFGTALKIAANVLPTAICKILKKC Hh: 25.00%
Ee: 29.17%
Cc: 45.83%		 24 80 (P. fluorescens)
10 (S. aureus)
6 (B. subtilis)
50 (C. albicans)		 [60]
Brevinin-1Sa Rana sphenocephala FLPAIVGAAGQFLPKIFCAISKKC Ee: 41.67%
Cc: 58.33%		 24 55 (E. coli) [61]
Brevinin-1Sb FLPAIVGAAGKFLPKIFCAISKKC Ee: 54.17%
Cc: 45.83%		 24 17 (E. coli)
Brevinin-1Sc FFPIVAGVAGQVLKKIYCTISKKC Ee: 62.50%
Cc: 37.50%		 24 14 (E. coli)
Brevinin-2 Rana brevipoda porsa GLLDSLKGFAATAGKGVLQSLLSTASCKLAKTC Hh: 39.39%
Ee: 6.06%
Cc: 54.55%		 33 4 (E. coli)
8 (S. aureus)		 [48]
Brevinin-2E Rana esculenta GIMDTLKNLAKTAGKGALQSLLNKASCKLSGQC Hh: 48.48%
Cc: 51.52%		 33 0.5 (E. coli D21)
0.2 (B. megaterium BmII)
2 (S. aureus Cowan 1)
>30 (P. aeruginosab ATCC15692)
NA (C. albican)
NA (S. cerevisiae)		 [43]
Brevinin-2Oa Rana ornativentris GLFNVFKGALKTAGKHVAGSLLNQLKCKVSGGC Hh: 42.42%
Ee: 27.27%
Cc: 30.30%		 33 2 (E. coli)
10 (S. aureus)
40 (C. albicans)		 [62]
Brevinin-2Ob GIFNVFKGALKTAGKHVAGSLLNQLKCKVSGEC Hh: 45.45%
Ee: 33.33%
Cc: 21.21%		 33 4 (E. coli)
9 (S. aureus)
40 (C. albicans)