Table 3.
The origin, primary structure, secondary structure, length, and antibacterial activity of ranatuerins. Secondary structure prediction was performed by GOR IV algorithm (https://npsa-prabi.ibcp.fr/cgi-bin/npsa_automat.pl?page=/NPSA/npsa_gor4.html accessed on 27 September 2022); Hh: Alpha helix; Ee: Extended strand; Cc: Random coil; MIC: Minimum inhibitory concentrations (μM); NA: not active.
| Peptides Name | Species | Primary Structure | Secondary Structure | Length | MIC (μM) | Ref. |
|---|---|---|---|---|---|---|
| Ranatuerin-1 | Rana catesbeiana | SMLSVLKNLGKVGLGFVACKINKQC | Ee: 40.00% Cc: 30.30% |
25 | 20 (E. coli) 20 (P. aeruginosa) 40 (K. pneumoniae) 20 (E. cloacae) >100 (P. mirabilis) 20 (S. aureus) 20 (S. epidermidis) 5 (Streptococcus Group B) 20 (E. faecalis) |
[64] |
| Ranatuerin-1C | Rana clamitans | SMLSVLKNLGKVGLGLVACKINKQC | Ee: 28.00% Cc: 72.00% |
25 | 1.5 (E. coli) 55 (S. aureus) 58 (C. albicans) 4 (E. coli) 17 (S. aureus) 14 (C. albicans) |
[65] |
| Ranalexin-1Ca | FLGGLMKAFPALICAVTKKC | Ee: 50.00% Cc: 50.00% |
20 | |||
| Ranatuerin-1T | Rana temporaria | GLLSGLKKVGKHVAKNVAVSLMDSLKCKISGDC | Hh: 36.36% Ee: 12.12% Cc: 51.52% |
33 | 40 (E. coli) | [66] |
| 120 (S. aureus) | ||||||
| 150 (C. albicans) | ||||||
| Ranatuerin-2AUa | Rana aurora aurora | GILSSFKGVAKGVAKNLAGKLLDELKCKITGC | Hh: 53.12% Ee: 9.38% Cc: 37.50% |
32 | 5 (E. coli) | [59] |
| 5 (P. aeruginosa) | ||||||
| 10 (K. pneumoniae) | ||||||
| 5 (E. cloacae) | ||||||
| >40 (P. mirabilis) | ||||||
| 20 (S. aureus) | ||||||
| 20 (S. epidermidis) | ||||||
| 5 (Streptococcus Group B) | ||||||
| >40 (E. faecalis) | ||||||
| Ranatuerin-2BYa | Rana boylii | ILSTFKGLAKGVAKDLAGNLLDKFKCKITGC | Hh: 48.39% Ee: 19.35% Cc: 32.26% |
31 | 7 (E. coli) 27 (S. aureus) NA (C. albicans) |
[50] |
| Ranatuerin-2BYb | IMDSVKGLAKNLAGKLLDSLKCKITGC | Hh: 44.44% Ee: 11.11% Cc: 44.44% |
27 | 17 (E. coli) NA (S. aureus) NA (C. albicans) |
||
| Ranatuerin-2Cb | Rana clamitans | GLFLDTLKGLAGKLLQGLKCIKAGCKP | Hh: 44.44% Ee: 7.41% Cc: 48.15% |
27 | 2 (E. coli) 40 (S. aureus) 46 (C. albicans) |
[65] |
| Ranatuerin-2CSa | Rana cascadae | GILSSFKGVAKGVAKDLAG KLLETLKCKITGC | Hh: 46.88% Ee: 18.75% Cc: 34.38% |
32 | 5 (E. coli) 10 (S. aureus) |
[67] |
| Ranatuerin-2Pb | Rana pipiens | SFLTTVKKLVTNLAALAGTVIDTIKCKVTGGCRT | Hh: 35.29% Ee: 32.35% Cc: 32.35% |
34 | 8 (E. coli) >256 (P. aeruginosa) 8 (S. aureus) 16 (MRSA) >512 (E. faecalis) 8 (C. albicans) |
[68] |
| Ranatuerin-2YJ |
Rana
dybowskii |
GLMDIFKVAVNKLLAAGMNKPRCKAAHC | Hh: 39.29% Ee: 17.86% Cc: 42.86% |
28 | 22.5 (E. coli) 22.5 (S. aureus) |
[69] |