Table 6.
The origin, primary structure, secondary structure, length, and antibacterial activity of bombinins. Secondary structure prediction was performed by GOR IV algorithm (https://npsa-prabi.ibcp.fr/cgi-bin/npsa_automat.pl?page=/NPSA/npsa_gor4.html accessed on 27 September 2022); Hh: Alpha helix; Ee: Extended strand; Cc: Random coil; MIC: Minimum inhibitory concentrations (μM); NA: not active.
| Peptides Name | Species | Primary Structure | Secondary Structure | Length | MIC (μM) | Ref. |
|---|---|---|---|---|---|---|
| BHL-bombinin | Bombina orientalis | GIGGALLSFGKSALKGLAKGLAEHF | Hh: 44.00% Ee: 24.00% Cc: 32.00% |
25 | 6.6 (E. coli) 26.2 (P. aeruginosa) 1.6 (S. aureus) 6.6 (MRSA) |
[96] |
| Bombinin HL | LLGPVLGLVSNVLGGLL | Ee: 58.82% Cc: 41.18% |
17 | NA (E. coli) NA (P. aeruginosa) 156.8 (S. aureus) NA (MRSA) |
||
| Bombinin-BO1 | Bombina orientalis | GIGSAILSAGKSIIKGLAKGLAEHF | Hh: 28.00% Ee: 20.00% Cc: 52.00% |
25 | 26.3 (E. coli) 26.3 (S. aureus) 52.5 (C. albicans) |
[97] |
| Bombinin H-BO1 | IIGPVLGLVGKALGGLL | Ee: 47.06% Cc: 52.94% |
17 | 26.3 (E. coli) 26.3 (S. aureus) 52.5 (C. albicans) |
||
| Bombinin H1 |
Bombina variegata | IIGPVLGMVGSALGGLLKKIG | Hh: 23.81% Ee: 38.10% Cc: 38.10% |
21 | 3.8 (E. coli D 21) 2.1 (S. aureus Cowan 1) |
[98] |
| Bombinin H3 | IIGPVLGMVGSALGGLLKKIG | Hh: 23.81% Ee: 38.10% Cc: 38.10% |
21 | 3.7 (E. coli D 21) 2.4 (S. aureus Cowan 1) |
||
| Bombinin H4 | LIGPVLGLVGSALGGLLKKIG | Hh: 23.81% Ee: 42.86% Cc: 33.33% |
21 | 4.8 (E. coli D 21) 3.3 (S. aureus Cowan 1) |